After the deaths of his parents, young Damien Thorn (Jonathan Scott-Taylor), now 13, has come to Chicago to live with his uncle, Richard Thorn (William Holden), a wealthy and influential industrialist, Richard’s wife, Ann (Lee Grant) and his son, Damien’s cousin, Mark (Lucas Donat). Only now is Damien beginning to understand his true identity and potential as the Son of Satan. But others are growing increasingly suspicious that he is not simply the appealingly charming, normal young man that he seems to be and that there is something more to him than first meets the eye. The dark forces which have surrounded and protected him since his birth, however, will not allow anyone or anything to get in the way of the destiny of the Antichrist. Between them, and Damien’s own growing ambition, anyone who crosses paths with him could end up marked for death.