"Naked Lunch" follows the fortunes of the very-William S. Burroughs-like Bill Lee (Peter Weller), an exterminator whose "bug powder" takes on narcotic qualities similar to heroin when his wife, Joan (Judy Davis) starts to inject the stuff as if it were a drug. Lee starts to feel its effects soon enough, when after he shoots Joan, he stumbles into an alternate reality (masquerading as an Islamic port town) called "interzone," where he learns that a bizarre species of insect is behind a massive government conspiracy. Along the way, Lee meets bunches of shape-shifting objects (his own typewriter seems to become a cockroach) and humans that are apparently little more than costumed bugs. Lee’s existence in the parallel worlds may never resolve itself, but the journey suggests nothing less.